1.1 Objectives of Subject 1.2 Related Subjects at MIT 1.3 Terminology 1.4 How Selected Tissues/Organs Function 1.5 Effects of Trauma and Disease on Function 1.6 Restoration of Function with Implants 1.7 Applications of Medial Devices and Examples Demonstrating the Successful and Unsuccessful Performance of Medical Devices/Implants 1.8 Design Considerations for Medical Devices and Non-medical Structures

2.1 Functional Performance of the Device(and Attachment to Tissue) 2.1.1 Mechanical 2.1.1.1Strength and Modulus of Elasticity: Modulus Matching 2.1.1.2 Tribology 2.1.2.3 Kinematics 2.1.2 Chemical 2.1.2.1 Drug Delivery/Controlled Release System

4.1 Performance Specifications 4.2 Biocompatibility 4.3 Degradation 4.4 Risk/Benefit ratio 4.5 Clinical Trial Design

3.1 Regeneration versus Repair 3.2 Matrices for Tissue Regeneration 3.2.1 Chemistry 3.2.1.1 Synthetic Polymers 3.2.1.2 Analogs of Extracellular Matrix: Collagen-GAG Copolymers 3.2.2 Pore Characteristics 3.2.3 Degradation Rate

5.1 Defining the Clinical Problem 5.2 Anatomical Considerations 5.3 Biomechanical Considerations 5.4 Functional Requirements 5.5 Goodness of Fit 5.6 Fixation

More Problems With Culture 1. The culture concept has been used and misused This notion has traveled around the world it can be considered one of Anthropology's great successes b. Culture has also been distorted 1. Assumptions that cultures have clear boundaries

1. Strength and weakness of anthropology: Anthropologists are often swayed by a single key case a. Weakness in that this is an obviously inadequate sample. No way of knowing if typical or how typical b. Strength in that rich analysis, really can tell you a lot

1.The Nuer a. Famous in anthropology long before Hutchinson's book i. The Nuer were pacified by the British colonial forces 1. After their pacification anthropologists could study them 2. Much of early anthropology was caught up in colonialism b. Studied by many, but there can't be a definitive book on their culture or any other

1. As an organizing principle for life a. We tend to think of kin as something natural biological or as having some basis beyond culture i. For example, children reuniting with birth parents b. Kinship is actually highly variable and artificial from one culture to the next

1. History and Anthropology a. Hutchinson emphasizes that her ethnography tries to encompass the history of the Nuer people b. Evans-Pritchard (Ep)on the other hand, tries only to capture the nuer at one moment in time