1. Concept of Glycobiology
1.#Concept#of#Glycobiology
Learning object: The classes of glycoconjugates and theirlocations in eukaryoticcells: The type of function served by glycosylation
Learning#object# • The#classes#of#glycoconjugates#and#their# loca;ons#in#eukaryo;c#cells# • The#type#of#func;on#served#by#glycosyla;on#
. The challenge of glycobiology is to define thebiologicalfunctions of sugars attached to proteinsandmembranesandtodeterminehowthesefunctions are carried out.: Although this challenge is ongoing, the principlesthat describe how protein- and lipid- linked sugarsmediate biological processes are becoming clear.· The goal of this lectureisto illustrate thethemesthat underlie the functions of glycoproteins andglycolipids by highlighting well-understood examplesof how the carbohydrate portions of these moleculeswork
• The#challenge#of#glycobiology#is#to#define#the# biological#func;ons#of#sugars#a?ached#to#proteins# and#membranes#and#to#determine#how#these# func;ons#are#carried#out.## • Although#this#challenge#is#ongoing,#the#principles# that#describe#how#proteinD#and#lipidD#linked#sugars# mediate#biological#processes#are#becoming#clear.# • The#goal#of#this#lecture#is#to#illustrate#the#themes# that#underlie#the#func;ons#of#glycoproteins#and# glycolipids#by#highligh;ng#wellDunderstood#examples# of#how#the#carbohydrate#por;ons#of#these#molecules# work.#
1.1 The field of glycobiologyencompasses the multiple functions ofsugars attached to proteins and lipids
1.1 The field of glycobiology encompasses the multiple functions of sugars attached to proteins and lipids
EnergymetabolismincellsPathwaytoabstract energyfrom breakdownofglucoseandglycogenGlycogen is even linked to protein coreThe function of sugar molecules as forms of energy for storageand transport isgenerally considered to fall outsidethefield ofglycobiology
Energy#metabolism#in#cells# Pathway#to#abstract#energy#from#breakdown#of# glucose#and#glycogen# Glycogen#is#even#linked#to#protein#core# The$func)on$of$sugar$molecules$as$forms$of$energy$for$storage$ and$transport$is$generally$considered$to$fall$outside$the$field$of$ glycobiology.$