The concept of Glycochemistryand Glycobiology1
The concept of Glycochemistry Glycochemistry and Gly gy cobiology 1
References☆"CarbohydrateChemistry"Benjamin G.DavisOxford UniversityPress 2002☆"Introduction to Glycobiology"2nd Ed.MaureenE.TaylorOxfordUniversityPress2003☆“Biochemistry"Garrett,4thEd.2008☆A varieties of papers"Essentials of Glycobiology"2nd Ed.AjitVarki2009“Functional and Molecular Glycobiology"BiOSscientificpublishers20022
“C b h d “Carbohydrate Ch i ” em stry” Bj i en am n G. D i av s Oxford University Press 2002 “Introduction to Glycobiology” 2nd Ed. Maureen E. Taylor Oxford University Press 2003 “Biochemistry” Garrett, 4th Ed. 2008 A varieties of p pa ers “Essentials of Glycobiology” 2nd Ed. Ajit Varki 2009 “Functional and Molecular Glycobiology” BIOS scientific publishers 2002 2
OutlineThe concept of glycochemistry and glycobiologyFischer Projection and the story behind*Open chain and ring structure ofmonosaccharidesReactions of the hydroxyl groupsReactionsoftheanomericcentreClassical Polysaccharides/as biocompatiblematerials*The development of Lock-key concept*N-linked glycosylation3
The concept concept of glycochemistry glycochemistry and glycobiology glycobiology Fischer Projection and the story behind Open chain and ring structure of monosaccharides Reactions of the hydroxyl groups Reactions Reactions of the anomeric anomeric centre Classical Polysaccharides/as biocompatible materials The development of Lock‐key concept N‐linked glycosylation 3
Outline*O-linked glycosylationGlycolipid and membrane protein glycosylationModern chemical and chemoenzymatic synthesisof oligosaccharides*Effect of glycosylation on protein structure andfunctionCarbohydrate recognition in cell adhesion andsignaling*Cyclodextrins/ourresearch*Update and Outlook
O‐linked glycosylation Glycolipid and membrane protein glycosylation Modern chemical chemical and chemoenzymatic chemoenzymatic synthesis synthesis of oligosaccharides Effect of gl li ycosylation on protein structure and function Carbohydrate recognition in cell adhesion and signaling Cyclodextrins/our research Update and Outlook 4
HOCH2CH,OHOHOHHHHOHHCH,OHOHHHoOHOHHHOHfructoseglucoseCH,OH0HOCHHHOH送私吃HOHHHHOHo1COHOHHOHsucrose